Extracellular Cyclic AMP/Adenosine Signaling Pathway: A Potential Pharmacological Target for Therapeutic Intervention in Chronic Lymphocytic Leukemia
نویسندگان
چکیده
The chronic lymphocytic leukemia (CLL) is the most prevalent type of leukemia in adults of western countries with an estimated annual 15,000 new cases and 4,500 deaths in the USA [1,2]. CLL is a disorder characterized by a progressive accumulation of biologically and functionally incompetent lymphocytes. Clinically, CLL is a heterogeneous disease with variable prognosis depending on the age affected, being dependent on the presence of associated comorbidities, clinical stage and expression of molecular markers specific to the disease [3-6].
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